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Moreover, madecassoside (MAD), isolated from Centella asiatica (Li et al., 2016) could repress the activation of the HGF-induced c-Met-PKC-ERK1/2-Cyclooxygenase-2 (COX-2)-Prostaglandin E2 (PGE2) cascade to inhibit HCC cell proliferation and invasion

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In both organisms, exposure to oxidative stress leads to the oxidation of a Cys residue on the glutathione peroxidase, Gpx3, which then forms an intermolecular disulfide bond with Cap1

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